About Diffuse Cutaneous Systemic Sclerosis (dcSSc)

A grandfather cutting his granddaughter's birthday cake at her party.

DcSSc1 is a subtype of systemic scleroderma, or systemic sclerosis, and is an autoimmune disease characterized by skin hardening, or fibrosis – caused by an excess of collagen in the body – and problems in many internal organs such as the lungs and kidneys.

Symptoms of dcSSc include Raynaud’s phenomenon, skin thickening beginning on the fingers and face that rapidly spreads throughout the body, spider veins, joint pain, acid reflux and difficulty eating. Some people may also experience more serious problems involving the lungs, heart and kidneys.

The cause of dcSSc is unknown, but researchers know that it originates from an autoimmune reaction that leads to an overproduction of collagen. Women and African Americans are more likely to be affected by dcSSc. Researchers believe that dcSSc may be related to genetics or exposure to infectious agents or drugs, but the exact cause is still unknown.2,3

There is no cure for dcSSc; however, certain medicines may slow the progression of dcSSc. Clinical research studies and volunteer participants are vital to the development of medicines that may slow disease progression in people with dcSSc. To see if you may be eligible to join us in this important research, we invite you to click or tap the button below to see if you qualify.

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  1. rarediseases.info.nih.gov/diseases/9751/diffuse-cutaneous-systemic-sclerosis
  2. orpha.net
  3. onlinelibrary.wiley.com/journal/25785745